Highlights
- You will unlock this event after completing Act 1 in Mewgenics.
- You need to defeat Guillotina three times, and each win gives a special quest item.
- Take Throbbing Gristle to the Wall of Flesh at the end of the Caves to open the secret area.
If you are trying to open the Wall of Flesh secret area in Mewgenics, you will need a special item called Throbbing Gristle. This item is a reward for defeating Guillotina, the first House Boss you face after Act 1. In this guide, we will show you how to get Throbbing Gristle, what it does during your run, and how to use it to unlock the secret area at the end of the Caves.
How to Open the Wall of Flesh Secret Area in Mewgenics

After you finish Act 1 in Mewgenics, you will see a cutscene with a warning: Guillotina is coming. She is the first House Boss in the game. You will need to defeat Guillotina three separate times. Each victory gives you a special quest item. If you are facing any problem in defeating Guilotina, read our guide on Mewgenics: Guillotina Boss Guide.
When you beat her the first time, you will get an item called Throbbing Gristle. Any unit that gets downed, whether it is an enemy or one of your own cats, will explode. And if your cat explodes, it is gone for the rest of that run. So you will need to be extra careful and try not to let anyone fall in battle. Once you have the Throbbing Gristle, take it to the Wall of Flesh at the end of the Caves to open it.
FAQs
- When does Guillotina appear in Mewgenics?
- She appears right after you complete Act 1. A cutscene will tell you that she is coming.
- How many times do you need to defeat Guillotina?
- You need to defeat her three separate times. Each victory gives you a quest item.
- Where do you use Throbbing Gristle?
- You need to take it to the Wall of Flesh at the end of the Caves to open the secret area.
